Best NFL Week 15 picks and predictions: ATS picks, upsets and score projections


Top NFL Week 15 Picks and Predictions: Against the Spread, Unexpected Upsets, and Score Projections.

Week 15 of the 2025 NFL season holds crucial matchups that could determine division races, playoff spots, and overall seeding. Teams like Buffalo, New England, Denver, and the Rams have the chance to clinch playoff berths with wins. The high stakes include teams like the Chiefs and Ravens fighting for their playoff lives. Lamar Jackson’s struggles make the Bengals favorites against the Ravens. The Packers face a tough Broncos defense, while the Seahawks are expected to dominate the Colts. The Cowboys are favored to beat the Vikings, and the Steelers are predicted to edge out the Dolphins. Other matchups and predictions for the week are also discussed.

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