2025 NFL Sao Paulo Game: Chiefs vs. Chargers odds, expert picks and predictions Chiefs vs. Charger odds, prediction: Model picks for 2025 NFL Sao Paulo Game

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Chiefs vs. Chargers Odds and Predictions for 2025 NFL Sao Paulo Game

The NFL returns to Brazil with the Kansas City Chiefs facing the Los Angeles Chargers in an AFC West matchup. The Chiefs are looking to bounce back after losing in the Super Bowl, while the Chargers are coming off a Wild Card loss. Quarterbacks Patrick Mahomes for the Chiefs and Justin Herbert for the Chargers lead their teams. Mahomes is supported by tight end Travis Kelce, while Herbert has wide receiver Ladd McConkey. SportsLine expert Mike Tierney has analyzed the game and is leaning towards the under on the point total. He also has a critical X-factor that points to one side of the spread.

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