Predictions for the first week of the 2025 NFL season with simulated outcomes and recommended bets: A potential 5-game parlay with odds of 25-1.
The Cincinnati Bengals face pressure on Day 1 of the 2025 NFL season against the Cleveland Browns. Bengals quarterback Joe Burrow had a near-MVP year in 2024 but Cincinnati still missed the playoffs. The Bengals, favored by 5.5 points, will play a Browns team led by Joe Flacco. In another key matchup, Aaron Rodgers and the Pittsburgh Steelers are 2.5-point favorites against the New York Jets. A computer model has predicted five confident NFL best bets for Week 1, including Washington Commanders (-6, 45.5) to cover against the New York Giants. Visit SportsLine for more Week 1 NFL picks with potential 25-1 payouts.
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