Week 5 NFL Odds for 2025: Lines, Spreads for all 14 Games
NFL Week 5 kicks off with the Rams hosting the 49ers. The lines for every Week 5 matchup at DraftKings Sportsbook reveal the odds for each game. Thursday night saw the 49ers beat the Rams with a spread of Rams -8.5 and total O/U of 43.5. Other matchups include Vikings vs. Browns, Broncos vs. Eagles, Raiders vs. Colts, Texans vs. Ravens, and more. The Patriots will face the Bills with a spread of Bills -8.5. Chiefs will play against Jaguars with a spread of Chiefs -3.5. To stay updated on NFL news, create or log in to your FOX Sports account.
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