NFL Week 2 picks for spread, over/under, and money-line based on computer model predictions
The 2025 Week 2 NFL schedule is packed with exciting matchups, including a Super Bowl rematch between the Eagles and Chiefs. Other key games include Commanders vs. Packers on Thursday, Broncos vs. Colts, Bears vs. Lions, and Giants vs. Cowboys on Sunday, and Buccaneers vs. Texans and Chargers vs. Raiders on Monday night. The Ravens are heavily favored to cover the spread against the Browns, with Lamar Jackson leading the charge. The SportsLine computer simulation model has been successful in predicting NFL outcomes, with several A-graded picks for Week 2. For more expert predictions and analysis, visit SportsLine.
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