2025 Wild Card Weekend NFL picks, odds, best bets by advanced model: This 5-way football parlay pays 25-1

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“NFL Picks and Best Bets for Wild Card Weekend 2025: Advanced Model Predictions and 5-Way Parlay with 25-1 Odds”

The 2025 NFL playoffs are kicking off with six games on Wild Card Weekend. Baltimore is favored by 10 points against Pittsburgh in a divisional matchup. Other games include Eagles vs. Packers and Rams vs. Vikings. The SportsLine computer model, which has a 69% success rate this year and a 65-35 record on top-rated NFL picks since Week 7 of 2022, has locked in five confident best bets for the weekend. One of their top picks is the Buffalo Bills to cover against the Denver Broncos. The model also recommends parlaying on four other NFL matchups for a chance at a massive payout of around 25-1. You can find all the model’s picks and predictions at SportsLine.

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