49ers vs. Seahawks Predictions, Odds, and Spread: Expert Model Insights for the 2026 NFL Divisional Round
The San Francisco 49ers will face the Seattle Seahawks in the NFC Divisional Round on Saturday, with a spot in the Championship Game on the line. San Francisco (12-5) advanced via a 23-19 wild-card win, while Seattle (14-3) earned a bye as the NFC’s top seed. The teams split their regular-season matchups. Seahawks QB Sam Darnold is questionable but expects to play, while 49ers WR Ricky Pearsall is also listed as questionable. Seattle is favored by 7 points, with an over/under of 45.5. SportsLine’s projection model has been profitable on NFL picks since its inception.
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