49ers vs. Panthers prediction, odds, spread: ‘Monday Night Football’ picks from proven computer

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Computer picks for 49ers vs. Panthers: Monday Night Football prediction, odds, spread

The San Francisco 49ers will host the Carolina Panthers on ‘Monday Night Football’. Both teams have alternated wins and losses in their recent games. San Fran is favored by 7 points and has key players returning from injuries. The Panthers, led by quarterback Bryce Young, have a strong defense and offense. The Niners, with a healthy Brock Purdy and Christian McCaffrey, have shown potential to score high. The model predicts the game to go over 49.5 points with the Niners covering the spread. Both teams have strengths, but the Niners appear to have the advantage.

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