Week 1 NFL betting guide: Odds, lines, picks, spreads, and top bets. Predictions for the 2025 season: Bengals and Packers high on the model’s list.
Some bettors prefer to place NFL bets early, while others wait until kickoff for maximum value. There are nearly a dozen close NFL games with lines of a field goal or less, including the Jets vs. Steelers at -3 and 49ers vs. Seahawks at +2.5. The model predicts the Bengals to cover the spread against the Browns due to Joe Burrow’s strong passing game. It also predicts the Packers to cover against the Lions, highlighting Green Bay’s defensive strengths. The model has made predictions for every game in Week 1, including underdogs that could win outright. Check SportsLine for all picks and predictions.
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