The Cowboys are the top pick by 16.5 points over the Giants, the largest point margin in the NFL this year.
The Dallas Cowboys are the heaviest favorites in the NFL this season, with a 16.5-point spread against the New York Giants. Giants quarterback Tommy DeVito, an undrafted rookie third-stringer, will be starting due to injuries to the starting and backup quarterbacks. Given DeVito’s lack of experience and the Cowboys’ strong defense, the outcome does not look promising for the Giants. The last time the NFL saw a point spread bigger than this was in Week 14 of last season when the Cowboys were also the favorites. They won that game 27-23 after a fourth-quarter comeback.
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