Thursday Night Football Picks: Giants vs. 49ers Odds, Line, Spread and NFL Predictions by Model on Impressive 164-117 Roll
The San Francisco 49ers are aiming for a rare 3-0 start as they play their home opener against the New York Giants on Thursday Night Football. The 49ers have won 12 consecutive regular-season games and have only started a season with three straight victories once in the last 25 seasons. The Giants suffered a humiliating loss in their season-opener but managed to rally from a 21-point deficit to secure a victory last week. Star running back Saquon Barkley may be out due to an ankle injury. The 49ers are favored by 10 points in the game.
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